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KMID : 0380219940270030217
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Journal of Biochemistry and Molecular Biology
1994 Volume.27 No. 3 p.217 ~ p.223
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Expression of mRNA for Fibrinogen During Mammary Carcinogenesis and the Mechanism of Metastasis by Tumor Fibrinogen
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Abstract
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Abstract:
@EN the expression of mRNa for fibrinogen during mammary carcinogenesis, and the mechanism of metastasis by fibrinogen, were studied. Fibrinogen is present in the cytosol in of SCK cells and mouse mammary carcinoma cells. mRNAs for the Aa-, Bβ-,
nad
Y-chains of fibrinogen are expressed only in full blown mamary carcinoma cells of rats administered 7,12-=dimethylbenzanthracene, SCK cells in a medium containing fibrinogen exhibited by cellular transglutaminase. The fibrinogen coating on the
surface
of the tumor cells protects against the lytic effect of LAK cells.
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